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Primary Osteoporosis in Young Adults: Genetic Basis and Identification of Novel Variants in Causal Genes.

ABSTRACT: Genetic determinants contribute to osteoporosis and enhance the risk of fracture. Genomewide association studies of unselected population-based individuals or families have identified polymorphisms in several genes related to low bone density, but not in osteoporotic patients with Z-score?

SUBMITTER: Collet C

PROVIDER: S-EPMC6124172 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Primary Osteoporosis in Young Adults: Genetic Basis and Identification of Novel Variants in Causal Genes.

Collet Corinne C Ostertag Agnès A Ricquebourg Manon M Delecourt Marine M Tueur Giulia G Isidor Bertrand B Guillot Pascale P Schaefer Elise E Javier Rose-Marie RM Funck-Brentano Thomas T Orcel Philippe P Laplanche Jean-Louis JL Cohen-Solal Martine M

JBMR plus 20171106 1

Genetic determinants contribute to osteoporosis and enhance the risk of fracture. Genomewide association studies of unselected population-based individuals or families have identified polymorphisms in several genes related to low bone density, but not in osteoporotic patients with <i>Z</i>-score < -2.0 SD with fragility fracture(s). The aim of this study was to determine the causal genes of idiopathic osteoporosis in the adulthood. Also, we used next-generation sequencing of candidate genes in a ...[more]

PMID: 30283887

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