Ontology highlight
ABSTRACT:
SUBMITTER: Elsegeiny W
PROVIDER: S-EPMC6124425 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Elsegeiny Waleed W Zheng Mingquan M Eddens Taylor T Gallo Richard L RL Dai Guixiang G Trevejo-Nunez Giraldina G Castillo Patricia P Kracinovsky Kara K Cleveland Hillary H Horne William W Franks Jonathan J Pociask Derek D Pilarski Mark M Alcorn John F JF Chen Kong K Kolls Jay K JK
JCI insight 20180621 12
Despite the discovery of key pattern recognition receptors and CD4+ T cell subsets in laboratory mice, there is ongoing discussion of the value of murine models to reflect human disease. Pneumocystis is an AIDS-defining illness, in which risk of infection is inversely correlated with peripheral CD4+ T cell counts. Due to medical advances in the control of HIV, the current epidemiology of Pneumocystis infection is predominantly due to primary human immunodeficiencies and immunosuppressive therapi ...[more]