Ontology highlight
ABSTRACT:
SUBMITTER: Zakaria C
PROVIDER: S-EPMC6124814 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Zakaria Chadi C Sean Polen P Hoang Huy-Dung HD Leroux Louis-Phillipe LP Watson Margaret M Workenhe Samuel Tekeste ST Hearnden Jaclyn J Pearl Dana D Truong Vinh Tai VT Robichaud Nathaniel N Yanagiya Akiko A Tahmasebi Soroush S Jafarnejad Seyed Mehdi SM Jia Jian-Jun JJ Pelin Adrian A Diallo Jean-Simon JS Le Boeuf Fabrice F Bell John Cameron JC Mossman Karen Louise KL Graber Tyson Ernst TE Jaramillo Maritza M Sonenberg Nahum N Alain Tommy T
PLoS pathogens 20180823 8
Herpes Simplex Virus 1 (HSV1) is amongst the most clinically advanced oncolytic virus platforms. However, efficient and sustained viral replication within tumours is limiting. Rapamycin can stimulate HSV1 replication in cancer cells, but active-site dual mTORC1 and mTORC2 (mammalian target of rapamycin complex 1 and 2) inhibitors (asTORi) were shown to suppress the virus in normal cells. Surprisingly, using the infected cell protein 0 (ICP0)-deleted HSV1 (HSV1-dICP0), we found that asTORi marked ...[more]