Ontology highlight
ABSTRACT:
SUBMITTER: Lin TV
PROVIDER: S-EPMC5056085 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Lin Tiffany V TV Hsieh Lawrence L Kimura Tomoki T Malone Taylor J TJ Bordey Angélique A
Proceedings of the National Academy of Sciences of the United States of America 20160919 40
Hyperactive mammalian target of rapamycin complex 1 (mTORC1) is a shared molecular hallmark in several neurodevelopmental disorders characterized by abnormal brain cytoarchitecture. The mechanisms downstream of mTORC1 that are responsible for these defects remain unclear. We show that focally increasing mTORC1 activity during late corticogenesis leads to ectopic placement of upper-layer cortical neurons that does not require altered signaling in radial glia and is accompanied by changes in layer ...[more]