Ontology highlight
ABSTRACT:
SUBMITTER: Ichikawa Y
PROVIDER: S-EPMC6125124 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Ichikawa Yuichi Y Saitoh Noriko N Kaufman Paul D PD
eLife 20180823
Nucleosomes contain two copies of each core histone, held together by a naturally symmetric, homodimeric histone H3-H3 interface. This symmetry has complicated efforts to determine the regulatory potential of this architecture. Through molecular design and in vivo selection, we recently generated obligately heterodimeric H3s, providing a powerful tool for discovery of the degree to which nucleosome symmetry regulates chromosomal functions in living cells (Ichikawa et al., 2017). We now have exte ...[more]