Ontology highlight
ABSTRACT:
SUBMITTER: Commisso B
PROVIDER: S-EPMC6125125 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Commisso Barbara B Ding Lingjun L Varadi Karl K Gorges Martin M Bayer David D Boeckers Tobias M TM Ludolph Albert C AC Kassubek Jan J Müller Oliver J OJ Roselli Francesco F
eLife 20180823
Amyotrophic lateral sclerosis (ALS) is characterized by the progressive degeneration of motoneurons in the primary motor cortex (pMO) and in spinal cord. However, the pathogenic process involves multiple subnetworks in the brain and functional MRI studies demonstrate an increase in functional connectivity in areas connected to pMO despite the ongoing neurodegeneration. The extent and the structural basis of the motor subnetwork remodeling in experimentally tractable models remain unclear. We hav ...[more]