Ontology highlight
ABSTRACT:
SUBMITTER: Imai H
PROVIDER: S-EPMC6125642 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Imai Hirotatsu H Abe Takaya T Miyoshi Tomohiro T Nishikawa Shuh-Ichi SI Ito Kosuke K Uchiumi Toshio T
Nucleic acids research 20180901 15
The ATP-binding cassette (ABC) protein ABCE1 is an essential factor in ribosome recycling during translation. However, the detailed mechanochemistry of its recruitment to the ribosome, ATPase activation and subunit dissociation remain to be elucidated. Here, we show that the ribosomal stalk protein, which is known to participate in the actions of translational GTPase factors, plays an important role in these events. Biochemical and crystal structural data indicate that the conserved hydrophobic ...[more]