Ontology highlight
ABSTRACT:
SUBMITTER: Krishnamoorthy G
PROVIDER: S-EPMC6126412 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Biochemistry and biophysics reports 20180903
Log D the logarithm ( log10 ) of the distribution coefficient ( D ), is one of the important parameters used in Lipinski's rule to assess the druggability of a molecule in pharmaceutical formulations. The distribution of a molecule between a hydrophobic organic phase and an aqueous buffer phase is influenced by the pH of the buffer system. In this work, we used both the conventional algebraic method and the generalized 'dynamic' approach to model the distribution coefficient of amphoteric, diami ...[more]