Ontology highlight
ABSTRACT:
SUBMITTER: Chawla AT
PROVIDER: S-EPMC6126694 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Chawla Ayesha T AT Cororaton Agnes D AD Idowu Michael O MO Damle Priyadarshan K PK Szomju Barbara B Ellis Keith C KC Patel Bhaumik B BB Grossman Steven R SR
Oncotarget 20180821 65
C-terminal binding protein 2 (CtBP2) drives intestinal polyposis in the <i>Apc</i><sup><i>min</i></sup> mouse model of human Familial Adenomatous Polyposis. As CtBP2 is targetable by an inhibitor of its dehydrogenase domain, understanding CtBP2's role in adenoma formation is necessary to optimize CtBP-targeted therapies in <i>Apc</i> mutated human neoplasia. Tumor initiating cell (TIC) populations were substantially decreased in <i>Apc</i><sup><i>min</i></sup><i>Ctbp2</i><sup><i>+/-</i></sup> in ...[more]