Ontology highlight
ABSTRACT:
SUBMITTER: Guo X
PROVIDER: S-EPMC6523041 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Guo Xingting X Huang Huanwei H Yang Ziqing Z Cai Tao T Xi Rongwen R
Stem cell reports 20190411 5
Intestinal stem cell (ISC) differentiation in the Drosophila midgut requires Delta/Notch-mediated lateral inhibition, which separates the fate of ISCs from differentiating enteroblasts (EBs). Although a canonical Notch signaling cascade is involved in the lateral inhibition, its regulation at the transcriptional level is still unclear. Here we show that the establishment of lateral inhibition between ISC-EB requires two evolutionarily conserved transcriptional co-repressors Groucho (Gro) and C-t ...[more]