Ontology highlight
ABSTRACT:
SUBMITTER: Marlow LA
PROVIDER: S-EPMC6126888 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Marlow Laura A LA Rohl Stephen D SD Miller James L JL Knauf Jeffery A JA Fagin James A JA Ryder Mabel M Milosevic Dragana D Netzel Brian C BC Grebe Stefan K SK Reddi Honey V HV Smallridge Robert C RC Copland John A JA
The Journal of clinical endocrinology and metabolism 20180901 9
<h4>Objective</h4>To investigate the molecular underpinnings of thyroid cancer, preclinical cell line models are crucial; however, ∼40% of these have been proven to be either duplicates of existing thyroid lines or even nonthyroid-derived lines or are not derived from humans at all. Therefore, we set out to establish procedures and guidelines that should proactively avoid these problems, which facilitated the creation of criteria to make valid preclinical models for thyroid cancer research.<h4>D ...[more]