Ontology highlight
ABSTRACT:
SUBMITTER: Garman B
PROVIDER: S-EPMC5709812 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Garman Bradley B Anastopoulos Ioannis N IN Krepler Clemens C Brafford Patricia P Sproesser Katrin K Jiang Yuchao Y Wubbenhorst Bradley B Amaravadi Ravi R Bennett Joseph J Beqiri Marilda M Elder David D Flaherty Keith T KT Frederick Dennie T DT Gangadhar Tara C TC Guarino Michael M Hoon David D Karakousis Giorgos G Liu Qin Q Mitra Nandita N Petrelli Nicholas J NJ Schuchter Lynn L Shannan Batool B Shields Carol L CL Wargo Jennifer J Wenz Brandon B Wilson Melissa A MA Xiao Min M Xu Wei W Xu Xaiowei X Yin Xiangfan X Zhang Nancy R NR Davies Michael A MA Herlyn Meenhard M Nathanson Katherine L KL
Cell reports 20171101 7
Tumor-sequencing studies have revealed the widespread genetic diversity of melanoma. Sequencing of 108 genes previously implicated in melanomagenesis was performed on 462 patient-derived xenografts (PDXs), cell lines, and tumors to identify mutational and copy number aberrations. Samples came from 371 unique individuals: 263 were naive to treatment, and 108 were previously treated with targeted therapy (34), immunotherapy (54), or both (20). Models of all previously reported major melanoma subty ...[more]