Ontology highlight
ABSTRACT:
SUBMITTER: Bonczek O
PROVIDER: S-EPMC6128526 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
PloS one 20180907 9
Tooth agenesis is one of the most common craniofacial disorders in humans. More than 350 genes have been associated with teeth development. In this study, we enrolled 60 child patients (age 13 to 17) with various types of tooth agenesis. Whole gene sequences of PAX9, MSX1, AXIN2, EDA, EDAR and WNT10a genes were sequenced by next generation sequencing on the Illumina MiSeq platform. We found previously undescribed heterozygous nonsense mutation g.8177G>T (c.610G>T) in MSX1 gene in one child. Muta ...[more]