Ontology highlight
ABSTRACT:
SUBMITTER: Xu D
PROVIDER: S-EPMC6128749 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Xu Daichao D Jin Taijie T Zhu Hong H Chen Hongbo H Ofengeim Dimitry D Zou Chengyu C Mifflin Lauren L Pan Lifeng L Amin Palak P Li Wanjin W Shan Bing B Naito Masanori Gomi MG Meng Huyan H Li Ying Y Pan Heling H Aron Liviu L Adiconis Xian X Levin Joshua Z JZ Yankner Bruce A BA Yuan Junying J
Cell 20180823 6
Aging is a major risk factor for both genetic and sporadic neurodegenerative disorders. However, it is unclear how aging interacts with genetic predispositions to promote neurodegeneration. Here, we investigate how partial loss of function of TBK1, a major genetic cause for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) comorbidity, leads to age-dependent neurodegeneration. We show that TBK1 is an endogenous inhibitor of RIPK1 and the embryonic lethality of Tbk1<sup>-/-</s ...[more]