Ontology highlight
ABSTRACT:
SUBMITTER: Dorigatti I
PROVIDER: S-EPMC6128884 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Dorigatti I I Donnelly C A CA Laydon D J DJ Small R R Jackson N N Coudeville L L Ferguson N M NM
Nature communications 20180907 1
CYD-TDV is the first licensed dengue vaccine for individuals 9-45 (or 60) years of age. Using 12% of the subjects enroled in phase-2b and phase-3 trials for which baseline serostatus was measured, the vaccine-induced protection against virologically confirmed dengue during active surveillance (0-25 months) was found to vary with prior exposure to dengue. Because age and dengue exposure are highly correlated in endemic settings, refined insight into how efficacy varies by serostatus and age is es ...[more]