Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.
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ABSTRACT:
SUBMITTER: Rafnar T
PROVIDER: S-EPMC6128903 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
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Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.
Rafnar Thorunn T Gunnarsson Bjarni B Stefansson Olafur A OA Sulem Patrick P Ingason Andres A Frigge Michael L ML Stefansdottir Lilja L Sigurdsson Jon K JK Tragante Vinicius V Steinthorsdottir Valgerdur V Styrkarsdottir Unnur U Stacey Simon N SN Gudmundsson Julius J Arnadottir Gudny A GA Oddsson Asmundur A Zink Florian F Halldorsson Gisli G Sveinbjornsson Gardar G Kristjansson Ragnar P RP Davidsson Olafur B OB Salvarsdottir Anna A Thoroddsen Asgeir A Helgadottir Elisabet A EA Kristjansdottir Katrin K Ingthorsson Orri O Gudmundsson Valur V Geirsson Reynir T RT Arnadottir Ragnheidur R Gudbjartsson Daniel F DF Masson Gisli G Asselbergs Folkert W FW Jonasson Jon G JG Olafsson Karl K Thorsteinsdottir Unnur U Halldorsson Bjarni V BV Thorleifsson Gudmar G Stefansson Kari K
Nature communications 20180907 1
Uterine leiomyomas are common benign tumors of the myometrium. We performed a meta-analysis of two genome-wide association studies of leiomyoma in European women (16,595 cases and 523,330 controls), uncovering 21 variants at 16 loci that associate with the disease. Five variants were previously reported to confer risk of various malignant or benign tumors (rs78378222 in TP53, rs10069690 in TERT, rs1800057 and rs1801516 in ATM, and rs7907606 at OBFC1) and four signals are located at established r ...[more]
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