Ontology highlight
ABSTRACT:
SUBMITTER: Matsumoto R
PROVIDER: S-EPMC6129131 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Matsumoto Reiko R Dainichi Teruki T Tsuchiya Soken S Nomura Takashi T Kitoh Akihiko A Hayden Matthew S MS Ishii Ken J KJ Tanaka Mayuri M Honda Tetsuya T Egawa Gyohei G Otsuka Atsushi A Nakajima Saeko S Sakurai Kenji K Nakano Yuri Y Kobayashi Takashi T Sugimoto Yukihiko Y Kabashima Kenji K
JCI insight 20180809 15
Epithelial cells are the first line of defense against external dangers, and contribute to induction of adaptive immunity including Th17 responses. However, it is unclear whether specific epithelial signaling pathways are essential for the development of robust IL-17-mediated immune responses. In mice, the development of psoriatic inflammation induced by imiquimod required keratinocyte TRAF6. Conditional deletion of TRAF6 in keratinocytes abrogated dendritic cell activation, IL-23 production, an ...[more]