Experimental microbial dysbiosis does not promote disease progression in SIV-infected macaques.
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ABSTRACT:
SUBMITTER: Ortiz AM
PROVIDER: S-EPMC6129204 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Experimental microbial dysbiosis does not promote disease progression in SIV-infected macaques.
Ortiz Alexandra M AM Flynn Jacob K JK DiNapoli Sarah R SR Vujkovic-Cvijin Ivan I Starke Carly E CE Lai Stephen H SH Long MacKenzie E ME Sortino Ornella O Vinton Carol L CL Mudd Joseph C JC Johnston Leslie L Busman-Sahay Kathleen K Belkaid Yasmine Y Estes Jacob D JD Brenchley Jason M JM
Nature medicine 20180730 9
Intestinal microbial dysbiosis has been described in individuals with an HIV-1 infection and may underlie persistent inflammation in chronic infection, thereby contributing to disease progression. Herein, we induced an HIV-1-like intestinal dysbiosis in rhesus macaques (Macaca mulatta) with vancomycin treatment and assessed the contribution of dysbiosis to SIV disease progression. Dysbiotic and control animals had similar disease progression, indicating that intestinal microbial dysbiosis simila ...[more]
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