Ontology highlight
ABSTRACT:
SUBMITTER: Hadwen J
PROVIDER: S-EPMC6132359 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Hadwen Jeremiah J Farooq Faraz F Witherspoon Luke L Schock Sarah S Mongeon Kevin K MacKenzie Alex A
Clinical and translational science 20180607 5
Duchenne muscular dystrophy is a recessive X-linked disease characterized by progressive muscle wasting; cardiac or respiratory failure causes death in most patients by the third decade. The disease is caused by mutations in the dystrophin gene that lead to a loss of functional dystrophin protein. Although there are currently few treatments for Duchenne muscular dystrophy, previous reports have shown that upregulating the dystrophin paralog utrophin in Duchenne muscular dystrophy mouse models i ...[more]