Ontology highlight
ABSTRACT:
SUBMITTER: Woodhead JL
PROVIDER: S-EPMC6132362 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Clinical and translational science 20180607 5
Elevations of liver enzymes have been observed in clinical trials with BAL30072, a novel antibiotic. In vitro assays have identified potential mechanisms for the observed hepatotoxicity, including electron transport chain (ETC) inhibition and reactive oxygen species (ROS) generation. DILIsym, a quantitative systems pharmacology (QSP) model of drug-induced liver injury, has been used to predict the likelihood that each mechanism explains the observed toxicity. DILIsym was also used to predict the ...[more]