Dataset Information

Availability of Additional Mediolateral Implant Option During Total Knee Arthroplasty Improves Femoral Component Fit Across Ethnicities: Results of a Multicenter Study.

ABSTRACT:

Background

Anatomical variation may represent a challenge in achieving a close fit between a prosthesis and a patient's osseous geometry in total knee arthroplasty (TKA). The purposes of this study were to determine whether the shape of the distal part of the femur differs among ethnicities, whether these differences affect the fit of the femoral component of a standard prosthesis, and whether the additional availability of a femoral component with a reduced mediolateral dimension for the same anteroposterior dimension improves femoral component fit across ethnicities.

Methods

Femoral dimensions were measured intraoperatively during 967 TKAs performed using the same type of prosthesis in patients of 5 different ethnicities. Aspect ratios were calculated to determine whether the shapes of the femora differed among ethnicities. The component fit ("perfect," overhang, or underhang) when only standard prostheses were available was compared with the fit when both standard and narrow prostheses were available in all ethnic groups. This enabled us to determine whether the femoral component fit was improved by the additional availability of the narrow version.

Results

Wide variations in shape were found among ethnicities as were variations among individuals of the same ethnicity. Differences in shape among ethnicities influenced the rate of overhang. However, overhang was more frequent at the trochlear than at the condylar level across all ethnicities. The availability of both the standard and the narrow femoral components improved the rate of a perfect fit in women in 3 of the 5 ethnic groups and reduced the overhang rate in women in all 5 of the ethnic groups. In contrast, only modest improvements in femoral component fit, which were not statistically significant, were seen in men.

Conclusions

The shape of the distal part of the femur varies not only among ethnicities but also within ethnic groups, leading to a high prevalence of overhang when only standard prostheses are available. The additional availability of a femoral component with a reduced mediolateral dimension for the same anteroposterior size can reduce overhang and improve component fit across ethnicities.

SUBMITTER: Sharma G

PROVIDER: S-EPMC6132471 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Publications

Availability of Additional Mediolateral Implant Option During Total Knee Arthroplasty Improves Femoral Component Fit Across Ethnicities: Results of a Multicenter Study.

Sharma Gaurav G Liu David D Malhotra Rajesh R Zhou Yi Xin YX Akagi Masao M Kim T K TK

JB & JS open access 20170518 2

<h4>Background</h4>Anatomical variation may represent a challenge in achieving a close fit between a prosthesis and a patient's osseous geometry in total knee arthroplasty (TKA). The purposes of this study were to determine whether the shape of the distal part of the femur differs among ethnicities, whether these differences affect the fit of the femoral component of a standard prosthesis, and whether the additional availability of a femoral component with a reduced mediolateral dimension for th ...[more]

PMID: 30229215

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Project description:BackgroundMore personalized implant designs for total knee arthroplasty might optimize the clinical outcome after surgery. One of these personalized implant designs is the Persona knee implant system (Zimmer Biomet, Warsaw, Indiana, USA). The primary objective of this study was to determine patient reported outcomes and implant survivorship of the Persona Knee system used in primary total knee arthroplasty, up to two years after surgery.MethodsFrom November 2013 to July 2016 consecutive patients undergoing primary total knee arthroplasty were enrolled in a prospective observational cohort study at three centers. Preoperatively, at 6 weeks, 6 months, 1 and 2 years after surgery, patients completed the Knee Injury and Osteoarthritis Outcome Score (KOOS), the Oxford Knee Score (OKS), the Knee Society Score (KSS, 2011, modified version) and the EQ-5D. Adverse Events were captured, assessed for relationship to device, and recorded in the study database. Furthermore, physical functioning was assessed by the orthopedic surgeon. Repeated measures analyses were performed on PROM scores. Kaplan Meier was used to calculate survivorship of the Persona Knee Implant System.ResultsA total of 146 total knee arthroplasties were performed. 61% (89/146) of the patients were female and mean age was 64.7 (± 6.9) years. Two years after surgery, one patient had a revision of the polyethylene insert because of a periprosthetic joint infection. Therefore, the Kaplan-Meier survival estimate at 2 years was 0.99 (0.95-1.00 95% CI). OKS increased from 22.1 (95% CI 20.9-23.3) to 41.8 (95% CI 40.6-43.1) two years after surgery. Furthermore, all other PROMs also increased from before surgery to 2 year postoperatively.ConclusionThe Persona Knee implant is safe and effective and the clinical results up to two years after surgery are promising. PROMs results are very good; pain, function and quality of life all improved greatly after TKA. Further studies are needed to determine the long term clinical performance of the Persona prosthesis.Trial registrationClinicaltrials.gov ( NCT02337244 ). Registered June 1st, 2015. Retrospectively registered.

Project description:The ideal local anesthetic regime for femoral nerve block that balances analgesia with mobility after total knee arthroplasty (TKA) remains undefined.We compared two volumes and concentrations of a fixed dose of ropivacaine for continuous femoral nerve block after TKA to a single injection femoral nerve block with ropivacaine to determine (1) time to discharge readiness; (2) early pain scores and analgesic consumption; and (3) functional outcomes, including range of motion and WOMAC scores at the time of recovery.Ninety-nine patients were allocated to one of three continuous femoral nerve block groups for this randomized, placebo-controlled, double-blind trial: a high concentration group (ropivacaine 0.2% infusion), a low concentration group (ropivacaine 0.1% infusion), or a placebo infusion group (saline 0.9% infusion). Infusions were discontinued on postoperative Day (POD) 2. The primary outcome was time to discharge readiness. Secondary outcomes included opioid consumption, pain, and functional outcomes. Ninety-three patients completed the study protocol; the study was halted early because of unanticipated changes to pain protocols at the host institution, by which time only 61% of the required number of patients had been enrolled.With the numbers available, the mean time to discharge readiness was not different between groups (high concentration group, 62 hours [95% confidence interval [CI], 51-72 hours]; low concentration group, 73 hours [95% CI, 63-83 hours]; placebo infusion group 65 hours [95% CI, 56-75 hours]; p = 0.27). Patients in the low concentration group consumed significantly less morphine during the period of infusion (POD 1, high concentration group, 56 mg [95% CI, 42-70 mg]; low concentration group, 35 mg [95% CI, 27-43 mg]; placebo infusion group, 48 mg [95% CI, 38-59 mg], p = 0.02; POD 2, high concentration group, 50 mg [95% CI, 41-60 mg]; low concentration group, 33 mg [95% CI, 24-42 mg]; placebo infusion group, 39 mg [95% CI, 30-48 mg], p = 0.04); however, there were no important differences in pain scores or opioid-related side effects with the numbers available. Likewise, there were no important differences in functional outcomes between groups.Based on this study, which was terminated prematurely before the desired sample size could be achieved, we were unable to demonstrate that varying the concentration and volume of a fixed-dose ropivacaine infusion for continuous femoral nerve block influences time to discharge readiness when compared with a conventional single-injection femoral nerve block after TKA. A low concentration of ropivacaine infusion can reduce postoperative opioid consumption but without any important differences in pain scores, side effects, or functional outcomes. These pilot data may be used to inform the statistical power of future randomized trials.Level II, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

Dataset Information

Availability of Additional Mediolateral Implant Option During Total Knee Arthroplasty Improves Femoral Component Fit Across Ethnicities: Results of a Multicenter Study.

Background

Methods

Results

Conclusions

Publications

Availability of Additional Mediolateral Implant Option During Total Knee Arthroplasty Improves Femoral Component Fit Across Ethnicities: Results of a Multicenter Study.

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