Gamma probe and ultrasound-guided fine needle aspiration cytology of the sentinel node (GULF) trial.

ABSTRACT:

Purpose

Sentinel lymph node biopsy (SLNB) was introduced as a minimally invasive technique for nodal staging. Since associated morbidity is not negligible, it is highly relevant to pursue a more minimally invasive alternative. The purpose of this study was to prospectively evaluate the sensitivity of fine needle aspiration cytology (FNAC) with combined gamma probe and ultrasound (US) guidance in comparison with the gold standard histology of the sentinel node (SN) after SLNB for detecting metastasis.

Methods

The study was designed as a prospective, multicentre, open-label, single-arm trial enrolling patients with newly diagnosed cutaneous melanoma or breast cancer between May 2015 and August 2017. Sample radioactivity was measured using a Mini 900 scintillation monitor. Afte

SUBMITTER: Verver D 

PROVIDER: S-EPMC6132503 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature