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Relationships between MRI fat distributions and sleep apnea and obesity hypoventilation syndrome in very obese patients.

ABSTRACT: PURPOSE:Obesity is associated with both obstructive sleep apnea (OSA) and obesity hypoventilation. Differences in adipose tissue distribution are thought to underlie the development of both OSA and hypoventilation. We explored the relationships between the distribution of upper airway, neck, chest, abdominal and muscle fat in very obese individuals. METHODS:We conducted a cross-sectional cohort study of individuals presenting to a tertiary sleep clinic or for assessment for bariatric surgery. Individuals underwent magnetic resonance (MR) imaging of their upper airway, neck, chest, abdomen and thighs; respiratory polygraphy; 1 week of autotitrating CPAP; and morning arterial blood gas to determine carbon dioxide partial pressure and base excess. RESULTS:Fifty-three individuals were included, with mean age of 51.6?±?8.4 years and mean BMI of 44.3?±?7.9 kg/m2; there were 27 males (51%). Soft palate, tongue and lateral wall volumes were significantly associated with the AHI in univariable analyses (p?

SUBMITTER: Turnbull CD

PROVIDER: S-EPMC6133118 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Relationships between MRI fat distributions and sleep apnea and obesity hypoventilation syndrome in very obese patients.

Turnbull C D CD Wang S H SH Manuel A R AR Keenan B T BT McIntyre A G AG Schwab R J RJ Stradling J R JR

Sleep & breathing = Schlaf & Atmung 20171202 3

<h4>Purpose</h4>Obesity is associated with both obstructive sleep apnea (OSA) and obesity hypoventilation. Differences in adipose tissue distribution are thought to underlie the development of both OSA and hypoventilation. We explored the relationships between the distribution of upper airway, neck, chest, abdominal and muscle fat in very obese individuals.<h4>Methods</h4>We conducted a cross-sectional cohort study of individuals presenting to a tertiary sleep clinic or for assessment for bariat ...[more]

PMID: 29197986

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Project description:RationaleAssociations between obstructive sleep apnea (OSA) and liver fat accumulation have been frequently investigated because both morbidities are common. Visceral fat was reported to be closely related to OSA and liver fat accumulation. Recently, sex differences in the association between OSA and mortality have gained much attention.ObjectivesTo investigate the associations among OSA, liver fat accumulation as determined by computed tomography, and visceral fat area and their sex differences.MethodsStudied were 188 males and 62 females who consecutively underwent polysomnography and computed tomography.ResultsAlthough the apnea-hypopnea index was positively correlated with liver fat accumulation in the total males, none of the OSA-related factors was independently associated with liver fat accumulation in either the total male or female participants in the multivariate analyses. When performing subanalyses using a specific definition for Japanese of obesity or visceral obesity (body mass index (BMI) ?25 kg/m2 or visceral fat area ?100 cm2), in only males without visceral obesity, percent sleep time with oxygen saturation <90%, in addition to BMI, insulin resistance, and serum triglyceride values, was independently correlated with liver fat accumulation (R2 = 15.1%, P<0.001). In males, percent sleep time of oxygen saturation <90% was also a determining factor for alanine aminotransferase values regardless of visceral fat area. In contrast, OSA was not associated with liver fat accumulation or alanine aminotransferase values in females whether or not visceral obesity was absent.ConclusionsSex differences in the visceral fat-dependent impact of OSA on liver fat accumulation existed. Although the mechanisms are not known and ethnic differences may exist in addition to the specific criteria of visceral obesity in Japan, the treatment of male patients with OSA might be favorable from the viewpoint of preventing liver fat accumulation and liver dysfunction even in patients without obvious visceral fat accumulation.

Dataset Information

Relationships between MRI fat distributions and sleep apnea and obesity hypoventilation syndrome in very obese patients.

Publications

Relationships between MRI fat distributions and sleep apnea and obesity hypoventilation syndrome in very obese patients.

Similar Datasets

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