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Relationships between MRI fat distributions and sleep apnea and obesity hypoventilation syndrome in very obese patients.

ABSTRACT: PURPOSE:Obesity is associated with both obstructive sleep apnea (OSA) and obesity hypoventilation. Differences in adipose tissue distribution are thought to underlie the development of both OSA and hypoventilation. We explored the relationships between the distribution of upper airway, neck, chest, abdominal and muscle fat in very obese individuals. METHODS:We conducted a cross-sectional cohort study of individuals presenting to a tertiary sleep clinic or for assessment for bariatric surgery. Individuals underwent magnetic resonance (MR) imaging of their upper airway, neck, chest, abdomen and thighs; respiratory polygraphy; 1 week of autotitrating CPAP; and morning arterial blood gas to determine carbon dioxide partial pressure and base excess. RESULTS:Fifty-three individuals were included, with mean age of 51.6?±?8.4 years and mean BMI of 44.3?±?7.9 kg/m2; there were 27 males (51%). Soft palate, tongue and lateral wall volumes were significantly associated with the AHI in univariable analyses (p?

SUBMITTER: Turnbull CD 

PROVIDER: S-EPMC6133118 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Relationships between MRI fat distributions and sleep apnea and obesity hypoventilation syndrome in very obese patients.

Turnbull C D CD   Wang S H SH   Manuel A R AR   Keenan B T BT   McIntyre A G AG   Schwab R J RJ   Stradling J R JR  

Sleep & breathing = Schlaf & Atmung 20171202 3

<h4>Purpose</h4>Obesity is associated with both obstructive sleep apnea (OSA) and obesity hypoventilation. Differences in adipose tissue distribution are thought to underlie the development of both OSA and hypoventilation. We explored the relationships between the distribution of upper airway, neck, chest, abdominal and muscle fat in very obese individuals.<h4>Methods</h4>We conducted a cross-sectional cohort study of individuals presenting to a tertiary sleep clinic or for assessment for bariat  ...[more]

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