Ontology highlight
ABSTRACT:
SUBMITTER: Tymanskyj SR
PROVIDER: S-EPMC6133550 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Tymanskyj Stephen R SR Yang Benjamin H BH Verhey Kristen J KJ Ma Le L
eLife 20180822
Neuronal cell morphogenesis depends on proper regulation of microtubule-based transport, but the underlying mechanisms are not well understood. Here, we report our study of MAP7, a unique microtubule-associated protein that interacts with both microtubules and the motor protein kinesin-1. Structure-function analysis in rat embryonic sensory neurons shows that the kinesin-1 interacting domain in MAP7 is required for axon and branch growth but not for branch formation. Also, two unique microtubule ...[more]