Dataset Information

Modeling clock-related metabolic syndrome due to conflicting light and food cues.

ABSTRACT: Most organisms possess a light- and food- entrainable circadian clock system enabling their adaptation to daily environmental changes in sunlight and food availability. The mammalian circadian system is composed of multiple clocks throughout the body. These local clocks are entrained by nutrient, neural, endocrine and temperature cues and drive diverse physiological functions including metabolism. In particular, the clock of the pancreatic ? cell rhythmically regulates the transcription of genes involved in glucose-stimulated insulin secretion. Perturbations of this fine-tuned oscillatory network increase the susceptibility to diseases. Besides chronic jet lag and shift work, common perturbations are ill-timed eating patterns which can lead to metabolic troubles (such as hypoinsulinemia). We have built a mathematical model describing the clock-dependent pancreatic regulation of glucose homeostasis in rodents. After calibrating the model using experimental data, we have investigated the effect of restricting food access to the normal rest phase. Our simulations show that the conflict between the light-dark cycle and the feeding-fasting cycle creates a differential phase shift in the expression of core clock genes (consistent with experimental observations). Our model further predicts that this induces a non-concomitance between nutrient cues and clock-controlled cues driving metabolic outputs which results in hypoinsulinemia, hyperglycemia as well as in a loss of food anticipation.

SUBMITTER: Woller A

PROVIDER: S-EPMC6134130 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Modeling clock-related metabolic syndrome due to conflicting light and food cues.

Woller Aurore A Gonze Didier D

Scientific reports 20180911 1

Most organisms possess a light- and food- entrainable circadian clock system enabling their adaptation to daily environmental changes in sunlight and food availability. The mammalian circadian system is composed of multiple clocks throughout the body. These local clocks are entrained by nutrient, neural, endocrine and temperature cues and drive diverse physiological functions including metabolism. In particular, the clock of the pancreatic β cell rhythmically regulates the transcription of genes ...[more]

PMID: 30206243

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Project description:Organisms from temperate ecosystems experience a cyclic alternation of favorable seasons, when they can grow and develop, and unfavorable periods, characterized by low temperatures and reduced resource availability. A common adaptation to these changing conditions is to undergo a state of metabolic arrest triggered by environmental cues (e.g. diapause) during the unfavorable periods. Altered environmental conditions resulting from global change can expose organisms to contradictory cues, potentially triggering maladaptive responses. Here, I compared the performance of an oligophagous butterfly when experiencing consistent vs contradictory environmental cues by manipulating temperature, daylength, and host plant in the laboratory. I implemented a fully factorial design with realistic temperature and photoperiodic regimes to resemble environmental conditions during mid-summer and the summer-autumn transition within the focal species' range. To assess the role of host plant at mediating the effects of abiotic factors, larvae were fed foliage of either a high or a low-quality host species. Decreasing daylength was the primary cue inducing diapause; however, feeding on a low-quality host at low temperatures also induced diapause in larvae growing under constant summer daylength. Conversely, exposure to high temperatures while feeding on a high-quality host occasionally overruled the diapause-inducing effect of decreasing daylength. Feeding on a high-quality host mitigated the lethal effects of cold, but not of hot temperatures. In addition, exposure to cold temperatures resulted in a significant reduction of pupal mass only under decreasing daylength. These results indicate that responses to environmental stressors in this multivoltine butterfly differ across the growing season according to the eco-physiological state of individuals (whether they undergo direct development or diapause). Traits related to oligophagy, such as sensitivity to multiple cues for diapause induction, as well as some of its consequences, such as the occurrence of overlapping generations, are likely to mitigate some of the detrimental effects of global change.

Dataset Information

Modeling clock-related metabolic syndrome due to conflicting light and food cues.

Publications

Modeling clock-related metabolic syndrome due to conflicting light and food cues.

Similar Datasets

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