Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus.
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ABSTRACT:
SUBMITTER: Munz M
PROVIDER: S-EPMC6135769 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
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Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus.
Munz Matthias M Richter Gesa M GM Loos Bruno G BG Jepsen Søren S Divaris Kimon K Offenbacher Steven S Teumer Alexander A Holtfreter Birte B Kocher Thomas T Bruckmann Corinna C Jockel-Schneider Yvonne Y Graetz Christian C Munoz Loreto L Bhandari Anita A Tennstedt Stephanie S Staufenbiel Ingmar I van der Velde Nathalie N Uitterlinden André G AG de Groot Lisette C P G M LCPGM Wellmann Jürgen J Berger Klaus K Krone Bastian B Hoffmann Per P Laudes Matthias M Lieb Wolfgang W Franke Andre A Dommisch Henrik H Erdmann Jeanette J Schaefer Arne S AS
Scientific reports 20180912 1
Evidence for a shared genetic basis of association between coronary artery disease (CAD) and periodontitis (PD) exists. To explore the joint genetic basis, we performed a GWAS meta-analysis. In the discovery stage, we used a German aggressive periodontitis sample (AgP-Ger; 680 cases vs 3,973 controls) and the CARDIoGRAMplusC4D CAD meta-analysis dataset (60,801 cases vs 123,504 controls). Two SNPs at the known CAD risk loci ADAMTS7 (rs11634042) and VAMP8 (rs1561198) passed the pre-assigned select ...[more]
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