Ontology highlight
ABSTRACT:
SUBMITTER: Ding Y
PROVIDER: S-EPMC6136352 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Ding Yahui Y Yang Zhongjin Z Ge Weizhi W Kuang Beijia B Xu Junqing J Yang Juan J Chen Yue Y Zhang Quan Q
Journal of enzyme inhibition and medicinal chemistry 20181201 1
A series of dithiocarbamate esters of parthenolide (PTL) was designed, synthesised, and evaluated for their anti- acute myelogenous leukaemia (AML) activities. The most promising compound 7l showed greatly improved potency against AML progenitor cell line KG1a with IC<sub>50</sub> value of 0.7 μM, and the efficacy was 8.7-folds comparing to that of PTL (IC<sub>50</sub> = 6.1 μM). Compound 7l induced apoptosis of total primary human AML cells and leukaemia stem cell (LSCs) of primary AML cells wh ...[more]