Ontology highlight
ABSTRACT:
SUBMITTER: Quy AS
PROVIDER: S-EPMC7695678 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Tetrahedron 20201101 48
Parthenolide exhibits anti-leukaemia activity, whilst its synthetic modification to impart improve drug-like properties, including 1,4-conjugate addition of primary and secondary amines, have previously been used, 1,4-addition of aniline derivatives to parthenolide has not been fully explored. A protocol for such additions to parthenolide is outlined herein. Reaction conditions were determined using tulipane as a model Michael acceptor. Subsequently, aniline-containing parthenolide derivatives w ...[more]