PTPN2 Downregulation Is Associated with Albuminuria and Vitamin D Receptor Deficiency in Type 2 Diabetes Mellitus.
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ABSTRACT:
SUBMITTER: Zheng L
PROVIDER: S-EPMC6136551 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
PTPN2 Downregulation Is Associated with Albuminuria and Vitamin D Receptor Deficiency in Type 2 Diabetes Mellitus.
Zheng Li L Zhang Wei W Li Aimei A Liu Yan Y Yi Bin B Nakhoul Farid F Zhang Hao H
Journal of diabetes research 20180830
<h4>Objective</h4>Inflammation plays a major role in albuminuria in type 2 diabetes mellitus (T2DM). Our previous studies have shown that the expression of vitamin D receptor (VDR) is downregulated in T2DM which is closely associated with the severity of albuminuria. In this study, we investigated the expression of anti-inflammatory cytokine protein tyrosine phosphatase nonreceptor type 2 (PTPN2) in T2DM and explored its relationship to albuminuria and VDR.<h4>Methods</h4>101 T2DM patients were ...[more]
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Project description: Not available
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