TGF?-induced transcription in cancer.
Ontology highlight
ABSTRACT:
SUBMITTER: Cantelli G
PROVIDER: S-EPMC6137079 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Publications
TGFΒ-induced transcription in cancer.
Cantelli Gaia G Crosas-Molist Eva E Georgouli Mirella M Sanz-Moreno Victoria V
Seminars in cancer biology 20160830
The Transforming Growth Factor-beta (TGFβ) pathway mediates a broad spectrum of cellular processes and is involved in several diseases, including cancer. TGFβ has a dual role in tumours, acting as a tumour suppressor in the early phase of tumorigenesis and as a tumour promoter in more advanced stages. In this review, we discuss the effects of TGFβ-driven transcription on all stages of tumour progression, with special focus on lung cancer. Since some TGFβ target genes are specifically involved in ...[more]
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