Ontology highlight
ABSTRACT:
SUBMITTER: Tye H
PROVIDER: S-EPMC6137172 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Nature communications 20180913 1
Anti-microbial signaling pathways are normally triggered by innate immune receptors when detecting pathogenic microbes to provide protective immunity. Here we show that the inflammasome sensor Nlrp1 aggravates DSS-induced experimental mouse colitis by limiting beneficial, butyrate-producing Clostridiales in the gut. The colitis-protective effects of Nlrp1 deficiency are thus reversed by vancomycin treatment, but recapitulated with butyrate supplementation in wild-type mice. Moreover, an activati ...[more]