Queuing up the ribosome: nutrition and the microbiome control protein synthesis.
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ABSTRACT:
SUBMITTER: Kozlovski I
PROVIDER: S-EPMC6138431 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Queuing up the ribosome: nutrition and the microbiome control protein synthesis.
Kozlovski Itamar I Agami Reuven R
The EMBO journal 20180903 18
The health of an organism is intricately linked to its gut microbiome. However, the mechanisms by which the microbiome affect the host gene regulation are still not well established. A new study by Tuorto <i>et al</i> (2018) shows that queuine, a nitrogenous base obtained from the gut microbiota, is used to modify tRNAs and affects cellular behavior. Dietary queuine is required for proper protein synthesis, and its depletion activates cellular stress responses <i>in vitro</i> and <i>in vivo</i>. ...[more]
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