Ontology highlight
ABSTRACT:
SUBMITTER: Sundaramoorthy E
PROVIDER: S-EPMC8106952 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Sundaramoorthy Elayanambi E Ryan Andrew P AP Fulzele Amit A Leonard Marilyn M Daugherty Matthew D MD Bennett Eric J EJ
Journal of cell science 20210428 8
Viral infection both activates stress signaling pathways and redistributes ribosomes away from host mRNAs to translate viral mRNAs. The intricacies of this ribosome shuffle from host to viral mRNAs are poorly understood. Here, we uncover a role for the ribosome-associated quality control (RQC) factor ZNF598 during vaccinia virus mRNA translation. ZNF598 acts on collided ribosomes to ubiquitylate 40S subunit proteins uS10 (RPS20) and eS10 (RPS10), initiating RQC-dependent nascent chain degradatio ...[more]