Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization.
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ABSTRACT:
SUBMITTER: Lee CC
PROVIDER: S-EPMC6138674 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
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Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization.
Lee Chih-Chan CC Lin Jiunn-Chang JC Hwang Wei-Lun WL Kuo Ying-Ju YJ Chen Hung-Kai HK Tai Shyh-Kuan SK Lin Chun-Chi CC Yang Muh-Hwa MH
Nature communications 20180914 1
A favorable interplay between cancer cells and the tumor microenvironment (TME) facilitates the outgrowth of metastatic tumors. Because of the distinct initiating processes between primary and metastatic tumors, we investigate the differences in tumor-associated macrophages (TAMs) from primary and metastatic cancers. Here we show that dual expression of M1 and M2 markers is noted in TAMs from primary tumors, whereas predominant expression of M2 markers is shown in metastatic TAMs. At metastatic ...[more]
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