Ontology highlight
ABSTRACT:
SUBMITTER: Kindt A
PROVIDER: S-EPMC6138742 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Kindt Alida A Liebisch Gerhard G Clavel Thomas T Haller Dirk D Hörmannsperger Gabriele G Yoon Hongsup H Kolmeder Daniela D Sigruener Alexander A Krautbauer Sabrina S Seeliger Claudine C Ganzha Alexandra A Schweizer Sabine S Morisset Rosalie R Strowig Till T Daniel Hannelore H Helm Dominic D Küster Bernhard B Krumsiek Jan J Ecker Josef J
Nature communications 20180914 1
Interactions between the gut microbial ecosystem and host lipid homeostasis are highly relevant to host physiology and metabolic diseases. We present a comprehensive multi-omics view of the effect of intestinal microbial colonization on hepatic lipid metabolism, integrating transcriptomic, proteomic, phosphoproteomic, and lipidomic analyses of liver and plasma samples from germfree and specific pathogen-free mice. Microbes induce monounsaturated fatty acid generation by stearoyl-CoA desaturase 1 ...[more]