Ontology highlight
ABSTRACT:
SUBMITTER: Hersh TA
PROVIDER: S-EPMC6139610 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Hersh Taylor A TA Dimond Alexandria L AL Ruth Brittany A BA Lupica Noah V NV Bruce Jacob C JC Kelley John M JM King Benjamin L BL Lutton Bram V BV
American journal of physiology. Regulatory, integrative and comparative physiology 20180411 2
The interaction between C-X-C chemokine receptor type 4 (CXCR4) and its cognate ligand C-X-C motif chemokine ligand 12 (CXCL12) plays a critical role in regulating hematopoietic stem cell activation and subsequent cellular mobilization. Extensive studies of these genes have been conducted in mammals, but much less is known about the expression and function of CXCR4 and CXCL12 in non-mammalian vertebrates. In the present study, we identify simultaneous expression of CXCR4 and CXCL12 orthologs in ...[more]