Ontology highlight
ABSTRACT:
SUBMITTER: Criswell KE
PROVIDER: S-EPMC8713815 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Criswell Katharine E KE Roberts Lucy E LE Koo Eve T ET Head Jason J JJ Gillis J Andrew JA
Proceedings of the National Academy of Sciences of the United States of America 20211201 51
The axial skeleton of tetrapods is organized into distinct anteroposterior regions of the vertebral column (cervical, trunk, sacral, and caudal), and transitions between these regions are determined by colinear anterior expression boundaries of <i>Hox5/6</i>, <i>-9</i>, <i>-10</i>, and <i>-11</i> paralogy group genes within embryonic paraxial mesoderm. Fishes, conversely, exhibit little in the way of discrete axial regionalization, and this has led to scenarios of an origin of <i>Hox</i>-mediate ...[more]