Ontology highlight
ABSTRACT:
SUBMITTER: Duong-Ly KC
PROVIDER: S-EPMC6140318 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Duong-Ly Krisna C KC Kuo Yin-Ming YM Johnson Matthew C MC Cote Joy M JM Kollman Justin M JM Soboloff Jonathan J Rall Glenn F GF Andrews Andrew J AJ Peterson Jeffrey R JR
Journal of cell science 20180905 17
T cell-mediated adaptive immunity requires naïve, unstimulated T cells to transition from a quiescent metabolic state into a highly proliferative state upon T cell receptor engagement. This complex process depends on transcriptional changes mediated by Ca<sup>2+</sup>-dependent NFAT signaling, mTOR-mediated signaling and increased activity of the guanine nucleotide biosynthetic inosine-5'-monophosphate (IMP) dehydrogenase 1 and 2 enzymes (IMPDH1 and IMPDH2, hereafter IMPDH). Inhibitors of these ...[more]