Ontology highlight
ABSTRACT:
SUBMITTER: Sandoval GJ
PROVIDER: S-EPMC6140332 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Molecular cell 20180802 4
Chromosomal rearrangements resulting in the fusion of TMPRSS2, an androgen-regulated gene, and the ETS family transcription factor ERG occur in over half of prostate cancers. However, the mechanism by which ERG promotes oncogenic gene expression and proliferation remains incompletely understood. Here, we identify a binding interaction between ERG and the mammalian SWI/SNF (BAF) ATP-dependent chromatin remodeling complex, which is conserved among other oncogenic ETS factors, including ETV1, ETV4, ...[more]