Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis.

ABSTRACT: The TMPRSS2-ERG fusion, present in approximately 50% of prostate cancers, is less common in prostatic intraepithelial neoplasia (PIN), raising questions about whether TMPRSS2-ERG contributes to disease initiation. We identified the translational start site of a common TMPRSS2-ERG fusion and showed that transgenic TMPRSS2-ERG mice develop PIN, but only in the context of PI3-kinase pathway activation. TMPRSS2-ERG-positive human tumors are also enriched for PTEN loss, suggesting cooperation in prostate tumorigenesis.

SUBMITTER: King JC 

PROVIDER: S-EPMC2898503 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature