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A second middle eastern kindred with autosomal recessive non-syndromic hearing loss segregates DFNB9.


ABSTRACT: A second kindred has been identified which supports the previously reported location of DFNB9. Linkage has been established to markers closely linked to DFNB9 which is located on 2p22-p23. The hearing impaired individuals in this highly consanguineous kindred from Eastern Turkey have prelingual profound hearing loss which affects all frequencies. A genetic map of the 2p22-p23 region where DFNB9 resides was generated using marker genotypes available from the CEPH database. All markers were placed on this genetic map using a likelihood ratio criterion of 1000:1. This map suggests that the region for DFNB9 is less than 1.08 cM, 95% confidence interval (0-2.59 cM).

SUBMITTER: Leal SM 

PROVIDER: S-EPMC6141006 | biostudies-literature | 1998 Jul-Aug

REPOSITORIES: biostudies-literature

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A second middle eastern kindred with autosomal recessive non-syndromic hearing loss segregates DFNB9.

Leal S M SM   Apaydin F F   Barnwell C C   Iber M M   Kandogan T T   Pfister M M   Braendle U U   Cura O O   Schwalb M M   Zenner H P HP   Vitale E E  

European journal of human genetics : EJHG 19980701 4


A second kindred has been identified which supports the previously reported location of DFNB9. Linkage has been established to markers closely linked to DFNB9 which is located on 2p22-p23. The hearing impaired individuals in this highly consanguineous kindred from Eastern Turkey have prelingual profound hearing loss which affects all frequencies. A genetic map of the 2p22-p23 region where DFNB9 resides was generated using marker genotypes available from the CEPH database. All markers were placed  ...[more]

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