Ontology highlight
ABSTRACT:
SUBMITTER: Kaminker R
PROVIDER: S-EPMC6141190 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Kaminker Revital R Anastasaki Athina A Gutekunst Will R WR Luo Yingdong Y Lee Sang-Ho SH Hawker Craig J CJ
Chemical communications (Cambridge, England) 20180801 69
N-Methylation of amino acids is an effective way to create protease resistance in both natural and synthetic peptides. However, alkyl substituents other than N-methyl have not been extensively studied. Here, we prepare and examine a series of N-substituted peptides in which the size and length of the alkyl group is modulated. These design insights provide a unique and modular handle for tuning proteolysis in oligopeptides. ...[more]