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Tuning of protease resistance in oligopeptides through N-alkylation.


ABSTRACT: N-Methylation of amino acids is an effective way to create protease resistance in both natural and synthetic peptides. However, alkyl substituents other than N-methyl have not been extensively studied. Here, we prepare and examine a series of N-substituted peptides in which the size and length of the alkyl group is modulated. These design insights provide a unique and modular handle for tuning proteolysis in oligopeptides.

SUBMITTER: Kaminker R 

PROVIDER: S-EPMC6141190 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Tuning of protease resistance in oligopeptides through N-alkylation.

Kaminker Revital R   Anastasaki Athina A   Gutekunst Will R WR   Luo Yingdong Y   Lee Sang-Ho SH   Hawker Craig J CJ  

Chemical communications (Cambridge, England) 20180801 69


N-Methylation of amino acids is an effective way to create protease resistance in both natural and synthetic peptides. However, alkyl substituents other than N-methyl have not been extensively studied. Here, we prepare and examine a series of N-substituted peptides in which the size and length of the alkyl group is modulated. These design insights provide a unique and modular handle for tuning proteolysis in oligopeptides. ...[more]

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