Ontology highlight
ABSTRACT:
SUBMITTER: Rolinski M
PROVIDER: S-EPMC7897519 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Roliński Miłosz M Montaldo Nicola Pietro NP Aksu Merdane Ezgi ME Fordyce Martin Sarah L SL Brambilla Alessandro A Kunath Nicolas N Johansen Jostein J Erlandsen Sten Even SE Liabbak Nina-Beate NB Rian Kristin K Bjørås Magnar M Sætrom Pål P van Loon Barbara B
Nucleic acids research 20210201 3
Alkylating drugs are among the most often used chemotherapeutics. While cancer cells frequently develop resistance to alkylation treatments, detailed understanding of mechanisms that lead to the resistance is limited. Here, by using genome-wide CRISPR-Cas9 based screen, we identify transcriptional Mediator complex subunit 13 (MED13) as a novel modulator of alkylation response. The alkylation exposure causes significant MED13 downregulation, while complete loss of MED13 results in reduced apoptos ...[more]