The structural basis for filovirus neutralization by monoclonal antibodies.
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ABSTRACT:
SUBMITTER: King LB
PROVIDER: S-EPMC6141344 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
The structural basis for filovirus neutralization by monoclonal antibodies.
King Liam B LB West Brandyn R BR Schendel Sharon L SL Saphire Erica Ollmann EO
Current opinion in immunology 20180622
Filoviruses, including ebolaviruses and marburgviruses, are the causative agents of highly lethal disease outbreaks. The 2013-2016 Ebola virus outbreak was responsible for >28000 infections and >11000 deaths. Although there are currently no licensed vaccines or therapeutics for any filovirus-induced disease, monoclonal antibodies (mAbs) are among the most promising options for therapeutic development. Hundreds of mAbs have been isolated from human survivors of filovirus infections that target th ...[more]
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