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Immunotherapy for esophageal squamous cell carcinoma: a review.

ABSTRACT: Cancer vaccines and immune checkpoint inhibitors (ICI) have recently been employed as immunotherapies for esophageal squamous cell carcinoma (ESCC). Cancer vaccines for ESCC have yielded several promising results from investigator-initiated phase I and II clinical trials. Furthermore, a Randomized Controlled Trial as an adjuvant setting after curative surgery is in progress in Japan. On the other hand, ICI, anti-CTLA-4 mAb and anti-PD-1 mAb, have demonstrated tumor shrinkage and improved overall survival in patients with multiple cancer types. For ESCC, several clinical trials using anti-PD-1/anti-PD-L1 mAb are underway with several recent promising results. In this review, cancer vaccines and ICI are discussed as novel therapeutic strategies for ESCC.

SUBMITTER: Mimura K

PROVIDER: S-EPMC6141453 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Immunotherapy for esophageal squamous cell carcinoma: a review.

Mimura Kosaku K Yamada Leo L Ujiie Daisuke D Hayase Suguru S Tada Takeshi T Hanayama Hiroyuki H Thar Min Aung Kyi AK Shibata Masahiko M Momma Tomoyuki T Saze Zenichiro Z Ohki Shinji S Kono Koji K

Fukushima journal of medical science 20180727 2

Cancer vaccines and immune checkpoint inhibitors (ICI) have recently been employed as immunotherapies for esophageal squamous cell carcinoma (ESCC). Cancer vaccines for ESCC have yielded several promising results from investigator-initiated phase I and II clinical trials. Furthermore, a Randomized Controlled Trial as an adjuvant setting after curative surgery is in progress in Japan. On the other hand, ICI, anti-CTLA-4 mAb and anti-PD-1 mAb, have demonstrated tumor shrinkage and improved overall ...[more]

PMID: 30058598

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