Ontology highlight
ABSTRACT:
SUBMITTER: Narrowe AB
PROVIDER: S-EPMC6143161 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Narrowe Adrienne B AB Spang Anja A Stairs Courtney W CW Caceres Eva F EF Baker Brett J BJ Miller Christopher S CS Ettema Thijs J G TJG
Genome biology and evolution 20180901 9
Diphthamide is a modified histidine residue which is uniquely present in archaeal and eukaryotic elongation factor 2 (EF-2), an essential GTPase responsible for catalyzing the coordinated translocation of tRNA and mRNA through the ribosome. In part due to the role of diphthamide in maintaining translational fidelity, it was previously assumed that diphthamide biosynthesis genes (dph) are conserved across all eukaryotes and archaea. Here, comparative analysis of new and existing genomes reveals t ...[more]