Cutting Edge: Elevated Leptin during Diet-Induced Obesity Reduces the Efficacy of Tumor Immunotherapy.
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ABSTRACT:
SUBMITTER: Murphy KA
PROVIDER: S-EPMC6143418 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
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Cutting Edge: Elevated Leptin during Diet-Induced Obesity Reduces the Efficacy of Tumor Immunotherapy.
Murphy Katherine A KA James Britnie R BR Sjaastad Frances V FV Kucaba Tamara A TA Kim Hyunjoon H Brincks Erik L EL Chua Streamson C SC Wilber Andrew A Griffith Thomas S TS
Journal of immunology (Baltimore, Md. : 1950) 20180822 7
Various malignancies are reproducibly cured in mouse models, but most cancer immunotherapies show objective responses in a fraction of treated patients. One reason for this disconnect may be the use of young, lean mice lacking immune-altering comorbidities present in cancer patients. Although many cancer patients are overweight or obese, the effect of obesity on antitumor immunity is understudied in preclinical tumor models. We examined the effect of obesity on two immunotherapeutic models: syst ...[more]
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