Ontology highlight
ABSTRACT:
SUBMITTER: McCloskey D
PROVIDER: S-EPMC6143558 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
McCloskey Douglas D Xu Sibei S Sandberg Troy E TE Brunk Elizabeth E Hefner Ying Y Szubin Richard R Feist Adam M AM Palsson Bernhard O BO
Nature communications 20180918 1
Biological regulatory network architectures are multi-scale in their function and can adaptively acquire new functions. Gene knockout (KO) experiments provide an established experimental approach not just for studying gene function, but also for unraveling regulatory networks in which a gene and its gene product are involved. Here we study the regulatory architecture of Escherichia coli K-12 MG1655 by applying adaptive laboratory evolution (ALE) to metabolic gene KO strains. Multi-omic analysis ...[more]