Ontology highlight
ABSTRACT:
SUBMITTER: Sternberg JR
PROVIDER: S-EPMC6143598 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Nature communications 20180918 1
Defects in cerebrospinal fluid (CSF) flow may contribute to idiopathic scoliosis. However, the mechanisms underlying detection of CSF flow in the central canal of the spinal cord are unknown. Here we demonstrate that CSF flows bidirectionally along the antero-posterior axis in the central canal of zebrafish embryos. In the cfap298<sup>tm304</sup> mutant, reduction of cilia motility slows transport posteriorly down the central canal and abolishes spontaneous activity of CSF-contacting neurons (CS ...[more]