Ontology highlight
ABSTRACT:
SUBMITTER: Vicentino ARR
PROVIDER: S-EPMC6143665 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Vicentino Amanda R R ARR Carneiro Vitor C VC Allonso Diego D Guilherme Rafael de Freitas RF Benjamim Claudia F CF Dos Santos Hílton A M HAM Xavier Fabíola F Pyrrho Alexandre Dos Santos ADS Gomes Juliana de Assis Silva JAS Fonseca Matheus de Castro MC de Oliveira Rodrigo C RC Pereira Thiago A TA Ladislau Leandro L Lambertucci José R JR Fantappié Marcelo R MR
Frontiers in immunology 20180912
In chronic schistosomiasis, liver fibrosis is linked to portal hypertension, which is a condition associated with high mortality and morbidity. High mobility group box 1 (HMGB1) was originally described as a nuclear protein that functions as a structural co-factor in transcriptional regulation. However, HMGB1 can also be secreted into the extracellular milieu under appropriate signal stimulation. Extracellular HMGB1 acts as a multifunctional cytokine that contributes to infection, injury, inflam ...[more]